abstract：:In this study the enzyme glutaminase, purified from the ascites fluid of ovarian cancer patients, was analysed for its antiangiogenic activity. Intraperitoneal administration of this enzyme reduces the number of tumor directed capillaries in solid and ascites tumor bearing Swiss mice induced by transplantation of Ehrl...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ghosh S,Roy S,Banerjee M,Maity P

更新日期：2004-12-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are a group of enzymes involved in the detoxification process of carcinogens and other substances. The genes encoding isoenzymes M1 and T1 have "null" alleles, which are polymorphic in humans. Our purpose was to examine whether the GSTM1 and GSTT1 homozygous null genotypes have an imp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tsabouri SE,Georgiou I,Katsaraki A,Bourantas KL

更新日期：2004-09-01 00:00:00

abstract：:The aim of this study was to investigate serum levels of IL-2, IL-6 and IL-10 in the pretreatment period and to determine if high IL-2, IL-6, IL-10 levels correlate with the outcome in patients with Non-Hodgkin's Lymphoma (NHL) in the post treatment period. Forty-three patients with the diagnosis of aggressive NHL wer...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ozdemir F,Aydin F,Yilmaz M,Kavgaci H,Bektas O,Yavuz MN,Yavuz AA

更新日期：2004-09-01 00:00:00

abstract：:Arsenic trioxide has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukemia (APL) as well as solid tumors. Arsenic can act through a considerable number of different pathways including mitochondrial respiration and tubulin formation, affecting growth, blood flow, diffe...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang TT,Brown SL,Kim JH

更新日期：2004-06-01 00:00:00

abstract：:This study is aimed at evaluating the inhibitory effects of the association of hematoporphyrin and ultrasound at variable intensities with a fixed frequency of 1.1MHz in tumor nodules. Specifically, the effects were studied both in solid and ascitic S180 tumors transplanted in mice by clinical, cytochemical and ultras...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Quan-hong L,Shi-hui S,Ya-ping X,Hao Q,Jin-xuan Z,Yao-hui R,Meng L,Pan W

更新日期：2004-06-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogenous group of hematological clonal malignancies. Patients belonging to the refractory anemia (RA) subtype are usually treated with recombinant human erythropoietin (EPO). Not all patients respond to EPO administration and they are strictly dependent on supportive therapy w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tsiara SN,Chaidos A,Gouva M,Christou L,Panteli K,Kapsali E,Bourantas KL

更新日期：2004-03-01 00:00:00

abstract：:A single guanine insertion (1G/2G polymorphism) in the promoter of the matrix metalloproteinase (MMP-1) gene creates a binding site for the transcription factor and may affect the level of transcription of MMP-1. An elevated level of MMP-1 in cancer cells may facilitate their invasion and contribute to metastasis. To ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Przybylowska K,Zielinska J,Zadrozny M,Krawczyk T,Kulig A,Wozniak P,Rykala J,Kolacinska A,Morawiec Z,Drzewoski J,Blasiak J

更新日期：2004-03-01 00:00:00

abstract：:Antioxidant, antitumor and anticarcinogenic activity of gossypin (3,5,8,3',4'-pentahydroxy-7-O glucosyl flavone) was carried out. The compound needed for 50% inhibition of superoxide, hydroxyl and nitric oxide radicals was 3 microg/ml, 41 microg/ml and 12 microg/ml, respectively. Gossypin also impart 50% inhibition at...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Babu BH,Jayram HN,Nair MG,Ajaikumar KB,Padikkala J

更新日期：2003-12-01 00:00:00

abstract：:Neoplastic transformation of heterotopic cervical salivary gland tissue is extremely rare. The Authors describe a case of pleomorphic adenoma arising in this tissue, on the right side of the neck in a 40-year old man. The characteristics of salivary heterotipias of the neck, and their diagnostic difficulties and histo...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Baldi A,Persichetti P,Di Marino MP,Nicoletti G,Baldi F

更新日期：2003-12-01 00:00:00

abstract：:Imatinib mesylate (IM), is a selective and competitive inhibitor of tyrosine kinases, including BCR-ABL, ABL, KIT, and the platelet-derived growth factor receptors (PDGF-R). It binds to the ATP-binding site of the target kinase and prevents the transfer of phosphate from ATP to the tyrosine residues of various substra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fiorentini G,Rossi S,Lanzanova G,Biancalani M,Palomba A,Bernardeschi P,Dentico P,De Giorgi U

更新日期：2003-12-01 00:00:00

abstract：:Radionuclide therapy with bone seeking radiopharmaceuticals is one of the oldest interventions in nuclear medicine and has been now in use for many years as an effective method of palliating painful bone metastases. Clinical indications have slowly but progressively increased starting from end-stage prostate cancer wi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Maini CL,Sciuto R,Romano L,Bergomi S

更新日期：2003-12-01 00:00:00

abstract：:After aggressive surgery and chemotherapy, patients (PTS) with advanced solid tumors have often an impaired immune function that may facilitate tumor relapse. We have demonstrated, in a phase IB study, that administering low-dose interleukin-2 (IL-2) and 13-cis retinoic acid (RA), there was a significant improvement o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Recchia F,Cesta A,Rea S

更新日期：2003-12-01 00:00:00

abstract：:Radiofrequency Thermal Ablation (RFA) of liver tumors is done by percutaneous, laparoscopic and open surgical approach. Selection criteria for percutaneous or open surgical ablation of 65 hepatic lesions are here evaluated in 45 patients treated in a two-years period. Twenty-five patients were males and 20 females, ag...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Crucitti A,Danza FM,Antinori A,Vincenzo A,Pirulli PG,Bock E,Magistrelli P

更新日期：2003-12-01 00:00:00

abstract：:Tumor ablation by radiofrequency (RFA) is an appealing therapeutical strategy for the treatment of liver tumors (hepatocarcinoma and metastatic lesions) to be used as valid alternative to the surgical resection that often is appropriate and feasible in only a minority of patients. RFA induces the localised and control...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rughetti A,Rahimi H,Rossi P,Frati L,Nuti M,Gaspari A,Danza FM,Ercoli L

更新日期：2003-12-01 00:00:00

abstract：:Naphthalmustine, 2-[2-[bis-(2-chloroethyl)amino]ethyl]-1H-benz[de]isoquinoline-1,3-dione (Compound 1) has been synthesized as a rationally designed new anticancer agent from N-(2-bromoethyl)naphthalimide. Its chemical alkylating activity exceeded that of nor-HN2 used as standard compound for comparison. Its antitumour...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pain A,Samanta S,Dutta S,Saxena AK,Shanmugavel M,Kampasi H,Qazi GN,Sanyal U

更新日期：2003-09-01 00:00:00

abstract：:Preclinical research and ongoing clinical trials are validating epidermal growth factor receptor (EGFR) as a suitable molecular target in cancer therapy. Here we report the case of a 39-year-old non-smoking man with heavily pretreated stage IV bronchioloalveolar NSCLC who was treated with gefitinib ('Iressa', ZD1839) ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gelibter A,Ceribelli A,Milella M,Mottolese M,Vocaturo A,Cognetti F

更新日期：2003-09-01 00:00:00

abstract：:Plant-derived phenolic compounds manifest many beneficial effects and can potentially inhibit several stages of carcinogenesis. In the present study, we investigated the efficacy of Emblica officinalis (E. officinalis) polyphenol fraction (EOP) on the induction of apoptosis in mouse and human carcinoma cell lineses an...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rajeshkumar NV,Pillai MR,Kuttan R

更新日期：2003-06-01 00:00:00

abstract：:In the deletion mapping of chromosome (chr) 9 in head and neck lesions of the Indian patient population by microsatellite markers, we have identified four discrete areas (D1-D4) with high loss of heterozygosities (LOHs) viz. 9p24-p23 (D1), 9p22-p21 (D2), 9q11-q13 (D3) and 9q22.3 (D4) regions. The deletions in D2 and D...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tripathi A,Dasgupta S,Roy A,Sengupta A,Roy B,Roychowdhury S,Panda CK

更新日期：2003-06-01 00:00:00

abstract：:The aim of the present study was to assess the role of virtual cystoscopy in the identification of bladder tumors. Fifteen patients (11 men and 4 women, median age: 61 years, range: 46-74 years) with a positive finding of bladder tumor at fiber-optic cystoscopy were studied by multislice-CT. Scans were downloaded to a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Marini M,Stasolla A,D'Aprile MR,Colaiacomo MC,Lo Mele L,Maccioni F,Iori S,Binda B,Izzo L

更新日期：2003-03-01 00:00:00

abstract：:Patients with ulcerative colitis (UC) have a higher incidence of colorectal cancer. UC-associated colorectal cancer is thought to develop in patients with preexisting UC-associated dysplasia. It is crucial to diagnose UC-associated dysplasia and early stage of cancer in patients with long-standing UC for the purpose o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fujii S,Fujimori T,Chiba T

更新日期：2003-03-01 00:00:00

abstract：:This study was undertaken to evaluate the statistical results of a large collected series of primary hepatic endocrinomas including carcinoids from extensive clinicopathologic aspect, and to provide the information to investigators engaged in this particular field of research. Primary hepatic endocrinomas variously te...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J

更新日期：2002-12-01 00:00:00

abstract：:This study was undertaken in order to verify if peri-operative serum lactate level changes, resulting from manipulation of the splanchnic circulation during pancreatectomy, reflected clinical outcome in twenty patients (9 males-11 females age 33 to 76) operated for pancreatic cancer. Lactate levels were evaluated at t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gruttadauria S,Marino IR,Vitale CH,Mandala L,Scott VL,Doria C

更新日期：2002-12-01 00:00:00

abstract：:Horseshoe kidney is a congenital anomaly of the upper urinary system frequently associated with atypical vascularization, mostly asymptomatic, usually undetected until the onset of infectious, obstructive or neoplastic complications. Although intravenous pyelography and US are useful tools, the role of CT is of vital ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Maccioni F,Stasolla A,D'Aprile MR,Binda B,Izzo L,Marini M

更新日期：2002-12-01 00:00:00

abstract：:Several models have been generated to estimate breast cancer risk and to predict the probability to identify a BRCA1 or BRCA2 germ line mutation. Each model, based on a slightly different study design and purpose, takes into account a definite number of relevant parameters and ultimately pertains to a specific cohort ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pasini B,Casalis Cavalchini GC,Genovese T,Manoukian S

更新日期：2002-09-01 00:00:00

abstract：:The continuous growth of a solid tumor is contingent upon the induction and formation of new vascular structures (angiogenesis). Several studies have established a close correlation between the microvessel density (MVD) of a tumor and its growth capacity. Therefore, a non-invasive method to accurately assess tumor MVD...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Carriero A,Ambrossini R,Mattei PA,Angelucci D,Bonomo L

更新日期：2002-09-01 00:00:00

abstract：:The incidence of bone metastasis was around 13% in 404 patients with hepatocellular carcinoma (HCC) who underwent treatment at the National Kyushu Cancer Center between 1988-97, which is a high value among various cancers. This is, in part, due to the prolonged survival time of HCC patients in recent years. Serum vasc...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Iguchi H,Yokota M,Fukutomi M,Uchimura K,Yonemasu H,Hachitanda Y,Nakao Y,Tanaka Y,Sumii T,Funakoshi A

更新日期：2002-09-01 00:00:00

abstract：:Gastric cancer, characterized by poor prognosis, remains a global health problem. Thus, it is important to describe the biological factors which can affect the prognosis in this disorder. The aim of our study was the determination of the relationship between apoptotic index (AI) and other clinicopathological features ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jesionek-Kupnicka D,Tenderenda M,Rutkowski P

更新日期：2002-09-01 00:00:00

abstract：:We report a case of a 72-year-old male, with a known history of non-Hodgkin lymphoma of the left tonsil for two years, histologically proved and successfully treated by radical surgical excision in combination with external radiotherapy. He presented with diffuse bone pain the last month, especially at the lower left ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pistevou-Gombaki K,Eleftheriadis N,Sofroniadis I,Makris P,Kouloulias V

更新日期：2002-09-01 00:00:00

abstract：:Axillary lymphadenectomy is a very important procedure in the staging of breast cancer patients. However, it is associated with a significant morbidity rate. On the other hand, using early diagnosis we can see a high number of cases where the lymph nodes are negatives. With the intention of avoiding unnecessary axilla...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zerwes FP,Frasson AL,Gutfilen B,Barbosa da Fonseca LM

更新日期：2002-06-01 00:00:00

abstract：:Pretreatment of ethyl acetate extract of Phellinus rimosus (Berk) Pilat protected cisplatin induced nephrotoxicity in mice. Single dose of the extract (25 and 50 mg/kg body weight) decreased cisplatin induced serum creatinine and urea levels. The cisplatin depleted renal antioxidant defence system, such as activity of...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ajith TA,Jose N,Janardhanan KK

更新日期：2002-06-01 00:00:00

abstract：:For a long time now we have been putting forwards the hypothesis that, when two cells belonging to different tissues of the same organism fuse, the nucleous/nuclei of the resulting "fused" cell could lay into a cytoplasm possibly containing factors influencing the activation or deactivation of genes able to interfere ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Sebastiani M,Soldati V

更新日期：2002-06-01 00:00:00

abstract：:Here we report the case of a patient with a soft tissue mass of the neck. For more than 10 years it was thought to be a branchial cyst and was later diagnosed to be a cystic lymph node metastasis from an occult thyroid carcinoma. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Appetecchia M,Meçule A,Sciarretta F

更新日期：2002-03-01 00:00:00

abstract：:This study was carried out to provide extensive information obtained from statistical analysis of laryngeal endocrinomas for the use of investigators working in this particular research field. A total of 278 patients with both typical and atypical varieties of carcinoids, and with small/oat cell carcinomas (SCC/OCC) e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Osaka M,Yakuwa Y

更新日期：2002-03-01 00:00:00

abstract：:The aim of this study was to assess the nuclear/cytoplasmic (N/C) ratio using computerized image analysis of cervical smears with intraepithelial neoplasia (CIN) grade I to III associated or not with cellular changes of human papillomavirus (HPV) in an attempt to determine if this method is more sensitive for the esti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Athanassiadou P,Kavantzas N,Gonidi M,Athanassiades P,Liossi A,Nakopoulou L,Petrakakou E,Davaris P

更新日期：2001-12-01 00:00:00

abstract：:p21WAF1,CIP1,SDI 1 is a specific inhibitor of cyclin-dependent kinase and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Cdk1/p34cdc2 plays a crucial role during mitosis. The immunoreactivity of p21 WAF1,CIP1,SDI 1 and cdk1/p34cdc2 was evaluated in adenomas and adenocarcinomas of the hum...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Egilmez R,Elagöz S,Kanik EA

更新日期：2001-12-01 00:00:00

abstract：:This study was carried out statistically to evaluate the present situation of carcinoids and related endocrine variants in the uterine cervix. A total of 205 patients who had been reported on in world-wide literature were divided into two groups; one, as a carcinoid group, consisting of 81 patients with carcinoids, 49...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Osaka M,Yakuwa Y

更新日期：2001-09-01 00:00:00

abstract：:We evaluated the effect of interferon-alpha2b as a chemosensitiser on HCT-15 cell line in treatment with doxorubicin. Chemosensitivity was determined by [3H]-thymidine incorporation and tetrazolium assays. The levels of expression of P-glycoprotein, Bcl-2 oncoprotein and HLA-ABC complex, and cell cycle/apoptosis analy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lucero Gritti MF,Beviacqua M,Bordenave RH,Rumi LS

更新日期：2001-09-01 00:00:00

abstract：:Since the social and financial impact of AML therapy is becoming more and more relevant we analyzed the cost of induction therapy of two different regimens. The first one is part of the widely employed EORTC-GIMEMA AML-10 and consists often days of therapy. The second (FLANG) is a short (three day), Fludarabine, Ara-C...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Clavio M,Quintino S,Masoudi B,Carrara S,Cerri R,Pierri I,Canepa L,Miglino M,Muner P,Damasio E,Gobbi M

更新日期：2001-06-01 00:00:00

abstract：:Tumor cells exhibit phenotypic and genotypic differences in comparison to normal cells. These differences can be used to identify proteins important for tumor growth and, therefore, potentially used in the diagnosis and follow-up of patients. The objective of this work was to investigate the electrophoretic pattern of...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Trejo-Becerril C,Pérez-Cárdenas E,Taja-Chayeb L,Zeichner-Gancz I,Delgado-Chávez R,Solorza-Luna G,Dueñas-González A

更新日期：2001-06-01 00:00:00

abstract：:Adenosquamous carcinomas of the colorectum are rare neoplasms. Our experience with two cases is presented in this paper. One patient, who complained of bloody stool, was found to have adenocarcinoma in the sigmoid colon. He received a laparoscopy-assisted sigmoidectomy. The histological examination revealed that the t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fukui R,Hata F,Yasoshima T,Furuhata T,Honma T,Nakajima F,Nishimori H,Isomura H,Katsuramaki T,Tanaka H,Kobayashi K,Hirata K

更新日期：2001-06-01 00:00:00